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Related Experiment Videos

Pregnancy in patients with rheumatic disease: anti-inflammatory cytokines increase in pregnancy and decrease post

M Østensen1, F Förger, J L Nelson

  • 1Department of Rheumatology and Clinical Immunology and Allergy, University Hospital, CH-3010 Bern, Switzerland. monika.oestensen@insel.ch

Annals of the Rheumatic Diseases
|November 13, 2004
PubMed
Summary

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Pregnancy impacts cytokine levels, with increased anti-inflammatory mediators like IL1Ra and sTNFR observed in pregnant patients with inflammatory arthritis. These changes correlate with disease activity, suggesting a role in managing rheumatoid arthritis (RA) and ankylosing spondylitis (AS).

Area of Science:

  • Immunology
  • Rheumatology
  • Reproductive Medicine

Background:

  • Rheumatoid arthritis (RA), juvenile idiopathic arthritis (JIA), and ankylosing spondylitis (AS) are chronic inflammatory conditions.
  • Pregnancy can alter immune system function and cytokine profiles.
  • Understanding these changes is crucial for managing inflammatory diseases during pregnancy.

Purpose of the Study:

  • To investigate changes in circulating cytokines, focusing on the Th1/Th2 balance.
  • To examine cytokine profiles during and after pregnancy in patients with RA, JIA, and AS.
  • To correlate cytokine levels with disease activity in pregnant patients.

Main Methods:

  • Plasma and serum samples analyzed from pregnant patients (RA, JIA, AS), healthy pregnant women, non-pregnant patients, and healthy non-pregnant women.

Related Experiment Videos

  • Quantification of interferon gamma (IFNγ), interleukin (IL) 1β, IL10, IL1 receptor antagonist (IL1Ra), soluble tumor necrosis factor receptor (sTNFR), and soluble CD30 (sCD30) using ELISA.
  • Clinical assessments and cytokine measurements performed during each trimester and at 6, 12, and 24 weeks postpartum.

    • Main Results:

    • IFNγ and IL10 levels were low or undetectable.
    • Significantly higher concentrations of sTNFR and IL1Ra were found in pregnant subjects compared to non-pregnant subjects.
    • Increased IL1Ra from the second to third trimester correlated with improved disease activity in RA and AS patients.
    • RA patients exhibited markedly elevated sCD30 levels during pregnancy compared to controls.

    Conclusions:

    • Th1 (IFNγ) and Th2 (IL10) response markers were largely undetectable.
    • Elevated levels of cytokine inhibitors (IL1Ra, sTNFR) are associated with pregnancy, independent of the underlying disease.
    • These anti-inflammatory mediators appear to influence disease activity in pregnant patients with inflammatory arthritis.