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Updated: Aug 21, 2026

Robust Mitochondrial Isolation from Rodent Cardiac Tissue
Published on: August 23, 2024
The mitochondrial death pathway and cardiac myocyte apoptosis
Michael T Crow1, Kartik Mani, Young-Jae Nam
1Department of Medicine, Johns Hopkins University School of Medicine, 5501 Hopkins Bayview Circle, Rm 5A.58, Baltimore, MD 21224, USA. mcrow1@jhmi.edu
Abstract:
Apoptosis has been causally linked to the pathogenesis of myocardial infarction and heart failure in rodent models. This death process is mediated by two central pathways, an extrinsic pathway involving cell surface receptors and an intrinsic pathway using mitochondria and the endoplasmic reticulum. Each of these pathways has been implicated in myocardial pathology. In this review, we summarize recent advances in the understanding of the intrinsic pathway and how it relates to cardiac myocyte death and heart disease.
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