Adipose tissue magnetic resonance imaging in the newborn
Sabita Uthaya1, Jimmy Bell, Neena Modi
1Division of Paediatrics, Obstetrics and Gynaecology, Chelsea and Westminster Hospital, Imperial College London, UK.
Insights
Infant body composition is crucial for health. New magnetic resonance imaging (MRI) accurately measures infant adipose tissue quantity and distribution, offering a direct, non-invasive assessment method for early development.
Area of Science:
- Pediatrics
- Medical Imaging
- Body Composition Analysis
Background:
- Infancy involves rapid adipose tissue accumulation, influencing long-term health.
- Adipose tissue quantity and distribution are key health and disease markers.
- Previous infant body composition methods were indirect and unreliable.
Purpose of the Study:
- To adapt and apply adipose tissue magnetic resonance imaging (MRI) for precise infant body composition assessment.
- To enable reliable quantification of adipose tissue depots and total adiposity in newborns.
- To establish a direct, non-invasive method for serial infant examinations.
Main Methods:
- Utilized magnetic resonance imaging (MRI) to directly assess adipose tissue.
- Adapted MRI technique for application in term and preterm newborns.
- Quantified individual adipose tissue depots and summed for total adiposity.
Main Results:
- Successfully adapted MRI for infant body composition analysis.
- Imaged over 100 term and preterm infants using the adapted MRI technique.
- Provided accurate, direct measurements of infant adipose tissue quantity and distribution.
Conclusions:
- Adipose tissue MRI is a direct, non-invasive, and radiation-free method for infant body composition.
- This technique allows for reliable assessment of both adipose tissue quantity and distribution in infants.
- The adapted MRI method is suitable for serial examinations during infancy, aiding in monitoring health and disease markers.
Abstract:
Infancy is a period of rapid adipose tissue accumulation, and influences during early development are plausible determinants of altered adiposity. The distribution, as well as the quantity of adipose tissue, is a marker of health and disease. Previous methods for the assessment of body composition in infants have been indirect and thus unable to determine adipose quantity reliably, nor assess adipose tissue distribution. Adipose tissue magnetic resonance imaging is direct, non-invasive, radiation free and suitable for serial examinations in infancy. Adipose tissue depots are quantified individually and summated to provide an accurate measure of depot-specific and total adiposity. We have adapted this technique for application to newborns and, to date, have imaged over 100 term and preterm infants.
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