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Antiphospholipid antibodies and hypertension
1Division of Nephrology, Ospedale San G. Bosco, Turin, Italy. nefro.gbosco@libero.it
Lupus
|November 16, 2004
Summary
Antiphospholipid antibodies (aPL) were not found in patients with renal artery stenosis (RAS). However, aPL were detected in 8% of essential hypertension patients, suggesting a potential link needing further research.
Area of Science:
- Cardiology
- Immunology
- Nephrology
Background:
- Hypertension is a known complication of antiphospholipid syndrome (APS).
- Antiphospholipid antibodies (aPL) have been observed in patients with hypertension linked to renal artery stenosis (RAS).
Observation:
- This study compared aPL presence in 26 RAS patients, 25 severe essential hypertension patients, and 61 healthy controls.
- Serum samples were analyzed for lupus anticoagulant (LA), anticardiolipin (aCL), antiprothrombin (aPT), and anti-beta2glycoprotein 1 (aβ2GP1) antibodies.
Findings:
- No aPL were detected in patients with RAS.
- aPL were found in 8% of essential hypertension patients, a higher prevalence than in the control group (1.6%).
- The association between RAS and aPL appears coincidental, not indicative of APS-related thrombosis.
Implications:
- The findings suggest a potential, albeit not fully understood, relationship between aPL and essential hypertension.
- Further large-scale studies are warranted to clarify the role of aPL in hypertension.
- The absence of aPL in RAS patients suggests it's not a specific thrombotic manifestation of APS.