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Evaluation of Biomaterials for Bladder Augmentation using Cystometric Analyses in Various Rodent Models
10:19

Evaluation of Biomaterials for Bladder Augmentation using Cystometric Analyses in Various Rodent Models

Published on: August 9, 2012

Bladder calculi after augmentation cystoplasty: risk factors and prevention strategies

William DeFoor1, Eugene Minevich, Pramod Reddy

  • 1Division of Pediatric Urology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio 45229-3039, USA. bob.defoor@cchmc.org

The Journal of Urology
|November 16, 2004
PubMed

Insights

Bladder augmentation in children has a low risk of stone formation. Gastrocystoplasty showed fewer stones than ileum or colon augmentation, with urinary tract infections being a key risk factor.

Area of Science:

  • Pediatric Urology
  • Surgical Reconstruction
  • Biomaterials Science

Background:

  • Lower urinary tract reconstruction is vital for managing pediatric bladder dysfunction.
  • Augmented bladders have a reported calculus incidence of up to 50%.

Purpose of the Study:

  • To analyze risk factors and outcomes of stone formation in augmented bladders in children.
  • To assess the incidence and management of bladder calculi after augmentation cystoplasty.

Main Methods:

  • Retrospective cohort study of 105 pediatric patients undergoing bladder augmentation (1988-2002).
  • Data abstracted included patient demographics, augmentation type (ileum, colon, stomach), risk factors, and management strategies.
  • Follow-up duration was a median of 8.4 years.

Main Results:

  • 11% of patients developed bladder calculi.
  • Ileum augmentation had the highest stone formation rate (27%), followed by colon (6%) and stomach (2%).
  • All patients with stones had recurrent urinary tract infections; endoscopic treatment was successful in most, but recurrence occurred in some despite medical management.

Conclusions:

  • Augmentation cystoplasty has a low overall risk of bladder calculi.
  • Gastrocystoplasty demonstrated a significantly lower stone formation rate compared to ileum and colon.
  • Urinary tract infection is an independent risk factor; recurrent stones may necessitate ongoing management.
Abstract

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