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Giant bladder diverticula causing bladder outlet obstruction in children
Aseem R Shukla1, Richard A Bellah, Douglas A Canning
1Division of Pediatric Urology, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania 19104-4399, USA.
Insights
Giant bladder diverticulum, a rare condition causing bladder outlet obstruction, can occur in infants and children. This study highlights a unique female case and emphasizes surgical diverticulectomy as the effective treatment.
Area of Science:
- Pediatric Urology
- Congenital Abnormalities
- Bladder Outlet Obstruction
Background:
- Congenital giant bladder diverticulum is a rare cause of bladder outlet obstruction in male infants, stemming from detrusor muscle deficiency.
- This condition can lead to significant voiding abnormalities.
Purpose of the Study:
- To investigate bladder outlet obstruction caused by congenital giant bladder diverticulum.
- To report the first known case of a female patient with this condition.
Main Methods:
- A 10-year retrospective review of 4 patients (3 male, 1 female) with bladder outlet obstruction due to giant bladder diverticulum.
- Analysis of prenatal and postnatal clinical and imaging records, including voiding cystourethrography (VCUG) and ultrasound.
Main Results:
- All patients presented with decreased urinary stream and retention; the female patient had Ehlers-Danlos syndrome and urinary tract infection.
- VCUG revealed giant bladder diverticula ( >7 cm) compressing the urethra during voiding in all patients.
- Two patients had vesicoureteral reflux and two had unilateral hydronephrosis; all underwent successful bladder diverticulectomy, with 3 requiring ureteral reimplantation.
Conclusions:
- Giant congenital bladder diverticulum descending below the bladder neck is a cause of bladder outlet obstruction.
- This study reports the first female case, suggesting connective tissue disorders may predispose patients.
- Surgical diverticulectomy, with or without ureteral reimplantation, is the recommended treatment for this condition.
Purpose:
Congenital giant diverticulum of the bladder is a consequence of deficiency in the detrusor musculature and has been reported in male infants as a rare cause of bladder outlet obstruction.
Materials And Methods:
A 10-year retrospective review revealed 4 patients (3 boys and 1 girl) with bladder outlet obstruction due to a giant bladder diverticulum. Prenatal and postnatal clinical and imaging records were reviewed.
Results:
Prenatal sonography was unremarkable in all patients. Three males (ages 4 months, 10 months and 3 years) had no medical history of voiding dysfunction, and 1 female (11 years) had the Ehlers-Danlos syndrome. While the girl presented with urinary tract infection, all patients presented with progressively decreasing urinary stream and urinary retention. Each patient underwent voiding cystourethrography (VCUG) and ultrasound. In each patient VCUG showed a giant (greater than 7 cm) bladder diverticulum that descended below the bladder neck and compressed the urethra during voiding. Vesicoureteral reflux was seen in 2 patients. Ultrasonography demonstrated moderate unilateral hydronephrosis in 2 patients. Bladder diverticulectomy was successfully performed in all patients, with ureteral reimplantation in 3.
Conclusions:
A giant congenital bladder diverticulum, when noted on VCUG to descend below the bladder neck, may lead to bladder outlet obstruction. To our knowledge we report the first case of a female presenting with bladder outlet obstruction due to a giant bladder diverticulum. Children with connective tissue disorders may be predisposed to this disorder, which must be excluded, regardless of gender, in all patients presenting with voiding abnormalities. Surgical diverticulectomy, often with ureteral reimplantation, is the preferred treatment, with excellent long-term results.
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