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Related Experiment Videos

Depigmented extramammary Paget's disease.

C-C Yang1, J Y-Y Lee, T-W Wong

  • 1Department of Dermatology, College of Medicine, National Cheng Kung University, 138 Sheng-Li Road, Tainan, Taiwan.

The British Journal of Dermatology
|November 16, 2004
PubMed
Summary

Depigmented extramammary Paget's disease (EMPD) may be more common than previously thought, presenting as white patches or macules. These depigmented lesions can indicate early disease or recurrence, necessitating biopsy for confirmation.

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Area of Science:

  • Dermatology
  • Oncology
  • Pathology

Background:

  • Depigmented extramammary Paget's disease (EMPD) is a rare variant, often presenting as depigmented macules or patches.
  • These lesions may be the sole indicator or accompany classical erythematous EMPD.

Purpose of the Study:

  • To determine the incidence and clinical characteristics of depigmentation in extramammary Paget's disease.
  • To evaluate the significance of depigmented lesions in EMPD diagnosis and recurrence.

Main Methods:

  • Retrospective review of pathology-proven EMPD cases diagnosed between 1990 and 2003.
  • Clinical photographs were analyzed for depigmentation; pathological confirmation involved cytokeratin 7, CEA, and mucin staining.

Main Results:

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  • Six out of 19 (30%) EMPD cases exhibited pathologically confirmed depigmented lesions.
  • Depigmentation appeared initially in two patients and as recurrence in four, with progressive enlargement suggesting it was not simple postinflammatory hypopigmentation.

Conclusions:

  • Depigmented EMPD is potentially underrecognized and may serve as an early sign or indicator of recurrence.
  • New or enlarging depigmented patches in EMPD patients warrant biopsy to rule out recurrence, rather than assuming postinflammatory changes.