Jove
Visualize
Contact Us

Related Experiment Videos

Confusion about measuring central nervous system effects.

Helmut G Madersbacher1

  • 1Neuro-Urology Unit , Landeskrankenhaus, University Hospital Innsbruck, Anichstrasse 35, A-6020 Innsbruck. helmut.madersbacher@tilak.at

Current Urology Reports
|November 16, 2004
PubMed
Summary

Anticholinergic drugs for overactive bladder can cause central nervous system (CNS) side effects, particularly in older adults. Understanding how these drugs cross the blood-brain barrier is key to managing potential cognitive and neurological impacts.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same journal

Single Port Robotic Surgery in Benign Urologic Disease - A Review of Contemporary Applications and Outcomes.

Current urology reports·2026
Same journal

Effective Mentorship in Urology Fellowship Training: Qualities, Models, and Equity.

Current urology reports·2026
Same journal

Management of Lower Urinary Tract Symptoms in Patients With Multiple Sclerosis.

Current urology reports·2026
Same journal

Lower Urinary Tract Symptoms as an Indicator of Occult Neurologic Disease: A System-first Framework for Urologic Practice.

Current urology reports·2026
Same journal

Association Between Ambient Temperature and Urolithiasis: A Systematic Review and Meta-analysis.

Current urology reports·2026
Same journal

Is Open Partial Nephrectomy Still an Option in the Robotic Era?

Current urology reports·2026
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Area of Science:

  • Pharmacology
  • Neuroscience
  • Geriatrics

Background:

  • Anticholinergic therapy and behavioral treatments are primary overactive bladder (OAB) management strategies.
  • Patient adherence and treatment success are significantly influenced by drug side effects.
  • Central nervous system (CNS) side effects of anticholinergics, especially in the elderly, have been historically under-addressed.

Purpose of the Study:

  • To investigate the central nervous system (CNS) side effects of anticholinergic drugs used for overactive bladder (OAB).
  • To explore the relationship between drug properties and their ability to penetrate the blood-brain barrier (BBB).
  • To analyze the impact of anticholinergics on brain function and structure.

Main Methods:

  • Utilized rapid eye movement (REM) sleep analysis to assess CNS effects.

Related Experiment Videos

  • Employed quantitative-topographic electroencephalogram (qEEG) studies for brain activity assessment.
  • Conducted psychometric testing to evaluate cognitive function.
  • Performed post-mortem brain morphology studies to analyze structural changes.

    • Main Results:

    • Anticholinergic drug properties influence their ability to cross the blood-brain barrier via passive and active transport.
    • CNS side effects are dependent on the pharmacokinetic and pharmacodynamic profiles of these medications.
    • Observed structural brain changes and functional alterations (sleep, EEG, cognitive) linked to anticholinergic use.

    Conclusions:

    • Central nervous system (CNS) side effects of anticholinergics are a critical consideration in overactive bladder (OAB) treatment, especially for the elderly.
    • Drug properties governing blood-brain barrier penetration are crucial determinants of CNS side effect incidence and severity.
    • Comprehensive assessment including sleep, EEG, psychometric, and morphological analyses is necessary to fully understand anticholinergic CNS effects.