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Updated: Aug 21, 2026

Differential Effects of Lipid-lowering Drugs in Modulating Morphology of Cholesterol Particles
Published on: November 10, 2017
Impact of nonprescriptive factors on low-density lipoprotein cholesterol reduction with statins
Joseph P Frolkis1, Gregory L Pearce, Dennis L Sprecher
1Division of General Internal Medicine and Health Care Research, Case Western Reserve University School of Medicine and University Hospitals of Cleveland, Cleveland, Ohio 44106, USA. jpf4@po.cwru.edu <jpf4@po.cwru.edu>
Abstract:
Nonprescriptive factors, including patient adherence, can affect the fluctuations in low-density lipoprotein (LDL) cholesterol observed in the clinical setting. In 241 statin-treated patients, although drugs and doses remained fixed, 57% of patients initially successful in reaching LDL cholesterol targets showed subsequent increases in LDL cholesterol. Conversely, 60% of patients who initially failed to reach targets had subsequent reductions in LDL cholesterol, with nearly 1/3 eventually attaining their LDL cholesterol goals.
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