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Updated: Aug 21, 2026

Implantation of Total Artificial Heart in Congenital Heart Disease
Published on: July 18, 2014
Initial experience with cardiac resynchronization therapy for ventricular dysfunction in young patients with
Margaret Strieper1, Peter Karpawich, Patrick Frias
1Sibley Heart Center, Children's Healthcare of Atlanta at Emory University, Atlanta, Georgia 30329, USA. strieperp@kidsheart.com <strieperp@kidsheart.com>
Insights
Cardiac resynchronization therapy (CRT) shows early promise for young patients with congenital heart disease and ventricular dysfunction. This study explores its long-term use in this population.
Area of Science:
- Pediatric Cardiology
- Electrophysiology
- Congenital Heart Disease
Background:
- Limited data exist on cardiac resynchronization therapy (CRT) in pediatric populations.
- Previous studies suggest acute benefits of CRT in young patients with specific post-surgical complications.
- No published data address the long-term management of systemic ventricular dysfunction in young patients with congenital heart disease using CRT.
Purpose of the Study:
- To describe the initial experience with CRT for long-term management of systemic ventricular dysfunction in pediatric patients with congenital heart disease.
- To evaluate the efficacy and safety of CRT in this specific, understudied population.
Main Methods:
- Retrospective analysis of pediatric patients with congenital heart disease receiving CRT.
- Assessment of clinical outcomes, including New York Heart Association classification, aerobic capacity, and ventricular contractility.
- Evaluation of device performance and adverse events.
Main Results:
- Early promising results in a young patient with congenital heart disease showed improvements in functional status and cardiac function post-CRT.
- Previous reports indicate acute benefits in young patients with postoperative right bundle branch block.
- This report details initial findings on the long-term application of CRT in this cohort.
Conclusions:
- Cardiac resynchronization therapy may offer a viable long-term management strategy for young patients with congenital heart disease and systemic ventricular dysfunction.
- Further research is warranted to confirm long-term efficacy and safety in this population.
- CRT represents a potential therapeutic option for improving quality of life and cardiac function in pediatric patients with complex heart conditions.
Abstract:
Data regarding cardiac resynchronization therapy (CRT) in pediatric patients are limited. The first reported use of CRT in a young patient with congenital heart disease showed promising early results with improvement in New York Heart Association classification, aerobic capacity, and ventricular contractility 1 month after implant. Other reports have shown acute benefits of CRT in young patients with postoperative right bundle branch block after surgery for congenital heart defects. To date, however, there are no published data regarding CRT for the long-term management of systemic ventricular dysfunction in the young with associated congenital heart disease. This report describes our initial experience with CRT in these patients.

