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Updated: Aug 21, 2026

Analysis of Oxidative Stress in Zebrafish Embryos
Published on: July 7, 2014
The role of oxidative damage and stress in aging
Alex Bokov1, Asish Chaudhuri, Arlan Richardson
1Department of Physiology, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229, USA.
Abstract:
The Free Radical/Oxidative Stress Theory of Aging, which was first proposed in 1956, is currently one of the most popular explanations for how aging occurs at the biochemical/molecular level. However, most of the evidence in support of this theory is correlative, e.g., oxidative damage to various biomolecules increases with age, and caloric restriction, which increases life span and retards aging, reduces the age-related increase in oxidative damage to biomolecules. The most direct test of the Free Radical/Oxidative Stress Theory of Aging is to specifically alter the age-related increase in oxidative damage and determine how this alteration affects life span. For the first time, investigators can use genetically altered animals to test directly the role of oxidative damage in aging. In this manuscript, we critically review the past research in this area and discuss potential future research directions in testing the Free Radical/Oxidative Theory of Aging.
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