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Deep brain stimulation of the subthalamic nucleus reduces antiparkinsonian medication costs

P David Charles1, Bimal B Padaliya, William J Newman

  • 1The Movement Disorders Clinic, Department of Neurology, Vanderbilt University Medical Center, 2100 Pierce Avenue, Suite 352 MCS, Vanderbilt University, Nashville, TN 37212-3375, USA. p.david.charles@vanderbilt.edu

Parkinsonism & Related Disorders
|November 16, 2004
PubMed

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Neurodegenerative disorders, such as Parkinson's Disease (PD), involve the gradual and irreversible destruction of neurons in particular brain areas. These disorders exhibit standard features like proteinopathies, selective vulnerability of some neurons, and an interaction of intrinsic properties, genetics, and environmental influences in neural injury.
Parkinson's Disease is primarily a result of the loss of dopaminergic neurons in the substantia nigra pars compacta. The cornerstone of its...