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Related Experiment Videos

Osteocyte density in woven bone.

C J Hernandez1, R J Majeska, M B Schaffler

  • 1Leni and Peter W. May Department of Orthopaedics, The Mount Sinai School of Medicine, New York, NY, USA. hernandez96@post.harvard.edu

Bone
|November 16, 2004
PubMed
Summary
This summary is machine-generated.

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Osteocyte density in woven bone varies by location and formation type. Endochondral woven bone, particularly near marrow spaces, shows significantly higher osteocyte density, suggesting faster remodeling.

Area of Science:

  • Bone Biology
  • Skeletal Tissue Engineering
  • Osteocyte Function

Background:

  • Woven bone is crucial for rapid bone formation during growth, injury, and anabolic stimulation.
  • Osteocytes are key regulators of bone remodeling, formation, and volume.
  • Differences in osteocyte density between woven and lamellar bone are hypothesized but lack extensive data.

Purpose of the Study:

  • To compare osteocyte lacunar density in rat lamellar bone versus woven bone formed under various conditions.
  • To investigate how skeletal site and developmental history influence osteocyte density in woven bone.

Main Methods:

  • Quantified osteocyte lacunar density (cells/mm²) in rat lamellar cortical and cancellous bone.
  • Compared lacunar density in periosteal woven bone (intramembranous) formed with and without mechanical loading.

Related Experiment Videos

  • Assessed lacunar density in woven bone within fracture callus (periosteal and endochondral) and primary spongiosa of the growth plate.

    • Main Results:

    • Lamellar cortical bone lacunar density was 834±83 cells/mm².
    • Periosteal woven bone lacunar density (921±204 cells/mm² under load, 1138±168 cells/mm² in callus buttress) did not differ significantly from lamellar bone.
    • Endochondrally derived woven bone in fracture callus (1875±270 cells/mm²) and primary spongiosa (1674±228 cells/mm²) showed significantly higher lacunar density (approx. 100% and 40% greater, respectively) than lamellar bone.

    Conclusions:

    • Osteocyte lacunar density in woven bone is site- and history-dependent.
    • Endochondrally derived woven bone, especially near marrow, exhibits elevated osteocyte density.
    • Increased osteocyte density in certain woven bone types may lead to accelerated bone remodeling rates.