Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Central respiratory carbon dioxide chemosensitivity does not decrease during sleep.

R A Parisi1, N H Edelman, T V Santiago

  • 1Department of Medicine, University of Medicine and Dentistry of New Jersey, Robert Wood Johnson Medical School, New Brunswick 08903-0019.

The American Review of Respiratory Disease
|April 1, 1992
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Genioglossal length and EMG responses to static upper airway pressures during hypercapnia in goats.

Respiration physiology·2001
Same author

Sleep and sleep disorders in pregnancy.

Annals of internal medicine·2001
Same author

Serotonergic stimulation of the genioglossus and the response to nasal continuous positive airway pressure.

American journal of respiratory and critical care medicine·2000
Same author

CO(2)/H(+) chemoreception in the cat pre-Bötzinger complex in vivo.

Journal of applied physiology (Bethesda, Md. : 1985)·2000
Same author

Hypoxic excitation in neurons cultured from the rostral ventrolateral medulla of the neonatal rat.

Journal of applied physiology (Bethesda, Md. : 1985)·2000
Same author

Pre-Bötzinger complex functions as a central hypoxia chemosensor for respiration in vivo.

Journal of neurophysiology·2000
Same journal

Human lung lysozyme: sources and properties.

The American review of respiratory disease·2015
Same journal

"Immotile-cilia" syndrome and ciliary abnormalities induced by infection and injury.

The American review of respiratory disease·2013
Same journal

Adult criteria for obstructive apnea do not identify children with serious obstruction.

The American review of respiratory disease·1993
Same journal

Cell adhesion molecules and the bronchial epithelium.

The American review of respiratory disease·1993
Same journal

Adhesion molecules and cytokine production.

The American review of respiratory disease·1993
Same journal

Molecular mechanisms mediating lymphocyte recirculation, inflammation, and metastasis formation.

The American review of respiratory disease·1993
See all related articles

Central CO2 chemosensitivity remains intact during sleep, despite reduced ventilatory responses. Increased brain blood flow during REM sleep, not altered chemoreceptor sensitivity, explains these changes in breathing regulation.

Area of Science:

  • Physiology
  • Neuroscience
  • Sleep Medicine

Background:

  • Ventilatory response to CO2 decreases during slow-wave sleep (SWS) and rapid-eye-movement (REM) sleep.
  • The extent to which decreased CO2 chemoreflex sensitivity contributes to this is unknown.
  • Mechanical factors or altered brain blood flow (BBF) during sleep may affect ventilatory output.

Purpose of the Study:

  • To investigate the central CO2 chemosensitivity during different sleep-wake states.
  • To determine the role of diaphragmatic electromyogram (EMGdI) and BBF in ventilatory changes during sleep.
  • To differentiate between altered chemosensitivity and mechanical factors influencing breathing during sleep.

Main Methods:

  • Measurements of ventilatory (VI), diaphragmatic electromyogram (EMGdI), and BBF responses to CO2 rebreathing in 10 goats across wakefulness, SWS, and REM sleep.

Related Experiment Videos

  • Analysis of the relationship between VI, EMGdI, and BBF changes relative to PaCO2.
  • Correlation analysis between EMGdI and BBF responses, and relationship of EMGdI to cerebral venous PCO2.

    • Main Results:

    • Ventilatory response to CO2 (delta VI/delta PaCO2) decreased significantly from wakefulness to SWS and REM sleep.
    • Diaphragmatic activity response to CO2 (delta EMGdI/delta PaCO2) decreased only during REM sleep.
    • Brain blood flow response to CO2 (delta BBF/delta PaCO2) increased during REM sleep, with a significant inverse correlation between delta EMGdI/delta PaCO2 and delta BBF/delta PaCO2.

    Conclusions:

    • Central CO2 chemosensitivity is intact during all sleep-wake states.
    • Increased BBF during REM sleep, rather than reduced chemosensitivity, contributes to the blunted ventilatory response.
    • The findings suggest that neural control of breathing during sleep is maintained, with adjustments in cerebrovascular and respiratory muscle activity.