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Unprecedented Barbier-type reactions catalysed by titanocene(III)
Antonio Rosales1, Juan L Oller-López, José Justicia
1Department of Organic Chemistry, Faculty of Sciences, University of Granada, Spain.
Chemical Communications (Cambridge, England)
|November 16, 2004
Abstract:
Selective Barbier-type allylations, benzylations and propargylations of aldehydes and ketones can be carried out under extremely mild conditions employing titanocene(III) complexes as catalysts. In this way, chiral titanocene catalysts provided yields ranging from 50-80% of optically active products.