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Related Experiment Videos

Inflammatory fibroid polyp: an immunohistochemical study.

Gilda da Cunha Santos1, Venâncio A F Alves, Alda Wakamatsu

  • 1Department of Pathology, School of Medicine, Federal University of São Paulo, Ribeirão Preto, SP, Brazil. gildacunha@uol.com.br

Arquivos De Gastroenterologia
|November 16, 2004
PubMed
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Inflammatory fibroid polyps, often found in the stomach, are reactive lesions. Immunohistochemistry suggests these polyps are primarily composed of fibroblasts, supporting an inflammatory origin rather than neural or vascular.

Area of Science:

  • Gastroenterology
  • Surgical Pathology
  • Immunohistochemistry

Background:

  • Inflammatory fibroid polyps (IFPs) are submucosal lesions of the gastrointestinal tract, predominantly the stomach.
  • Their nonneoplastic, reactive nature is widely accepted, yet their precise histogenesis remains debated.

Purpose of the Study:

  • To investigate the histogenesis of inflammatory fibroid polyps using immunohistochemistry.
  • To clarify the cellular origin and nature of these lesions.

Main Methods:

  • Analysis of nine IFP cases using immunohistochemistry.
  • Antibodies used included those for smooth-muscle actin, vimentin, S-100 protein, factor VIII-related antigen, and macrophage (HAM-56).

Main Results:

Related Experiment Videos

  • Spindle cells within the polyps showed strong, diffuse vimentin positivity and patchy smooth-muscle actin staining.
  • Immunophenotyping revealed heterogeneous HAM-56 reactivity, with distinct cellular morphologies observed in edematous versus cell-rich areas.
  • Stains for S-100 protein and factor VIII-related antigen were negative in the proliferating cells.

    • Conclusions:

    • The findings refute a neural or vascular origin for IFPs.
    • Strong vimentin positivity indicates fibroblasts as the predominant cell type.
    • The diverse morphological and immunohistochemical patterns suggest IFPs may represent different phases of an inflammatory process.