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[Orthostatic tremor induced by pharmaceuticals].
H Alonso-Navarro1, M Ortí-Pareja, F J Jiménez-Jiménez
1Departamento de Medicina-Neurología, Hospital Príncipe de Asturias, Universidad de Alcalá, Alcalá de Henares, Spain.
Revista De Neurologia
|November 16, 2004
Summary
Dopamine blocking drugs can cause various movement disorders. This study identifies a new condition, tardive orthostatic tremor, in patients exposed to these medications.
Area of Science:
- Neurology
- Pharmacology
Background:
- Dopamine blocking agents are known to induce various tardive syndromes.
- Orthostatic tremor has not been previously documented as a complication.
Observation:
- Four patients developed orthostatic tremor after exposure to dopamine blocking drugs.
- Two patients presented with predominant orthostatic tremor, while two had pure high-frequency orthostatic tremor.
Findings:
- Complete tremor resolution in three patients and marked improvement in one after drug withdrawal.
- The offending drugs included metoclopramide, sulpiride, and thyethylperazine.
Implications:
- Orthostatic tremor should be considered within the spectrum of drug-induced movement disorders.
- This finding expands the understanding of tardive syndromes associated with dopamine blocking agents.