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Related Experiment Videos

Homochirality and life.

Noriko Fujii1, Takeshi Saito

  • 1Research Reactor Institute, Kyoto University Kumatori, Sennan, Osaka 590-0494, Japan. nfujii@HL.rri.kyoto-u.ac.jp

Chemical Record (New York, N.Y.)
|November 16, 2004
PubMed
Summary

D-amino acids, once thought absent in life, are now found in organisms and play vital physiological roles. This review explores their presence and function in biological systems.

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Area of Science:

  • Biochemistry
  • Molecular Biology
  • Physiology

Background:

  • Amino acids exist as left-handed (L) and right-handed (D) enantiomers.
  • Historically, L-amino acids dominated life, with D-amino acids presumed absent.
  • Recent analytical advancements reveal D-amino acids in complex organisms.

Purpose of the Study:

  • To review the presence and physiological functions of D-amino acids in higher organisms.
  • To describe D-amino acid biosystems within the body.

Main Methods:

  • Literature review of studies on D-amino acid occurrence and function.
  • Analysis of D-amino acids in free form, peptides, and proteins.
  • Examination of D-amino acid roles in physiological processes.

Main Results:

  • D-amino acids are present in free form, peptides, and proteins in living organisms.
  • Free D-amino acids exhibit significant physiological functions.
  • D-amino acid-containing peptides act as opioid peptides.
  • D-amino acids in proteins are linked to the aging process.

Conclusions:

  • D-amino acids are integral components of biological systems with diverse functions.
  • Understanding D-amino acid biosystems is crucial for comprehending physiology and aging.
  • Further research into D-amino acid roles is warranted.

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