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Updated: Aug 15, 2026
Simultaneous Affinity Enrichment of Two Post-Translational Modifications for Quantification and Site Localization
Published on: February 27, 2020
Strategies for shotgun identification of post-translational modifications by mass spectrometry
1Department of Cell Biology, The Scripps Research Institute, 10550 North Torrey Pines Road SR11, La Jolla, CA 92037, USA.
Abstract:
The global identification of post-translationally modified proteins is a difficult challenge that is currently being addressed by many researchers in the field of mass spectrometry (MS)-based proteomics. The ability to identify thousands of proteins by shotgun-based strategies has made the mere idea of a global analysis of a particular protein modification seem reasonable. There has been much progress in the development of methods that make use of shotgun-based protein identification in the analysis of a wide variety of protein modifications, some of which will be discussed here.
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