Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Monocyte derived dendritic cell responses in common variable immunodeficiency.

T H Scott-Taylor1, M R J Green, E Eren

  • 1Department of Immunology, Royal Free Campus, University College London, London, UK. t.scott-taylor@rfc.ucl.ac.uk

Clinical and Experimental Immunology
|November 17, 2004
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Preoperative virtual stoma site marking in colorectal surgery: a pilot study exploring a telemedicine-based solution for limited-access settings.

Techniques in coloproctology·2025
Same author

Diagnostic value of routine haematological and biochemical testing in clinically healthy ASA I cats undergoing elective ovariohysterectomy and orchiectomy.

The Journal of small animal practice·2025
Same author

HETEROKARYOTIC MONOZYGOTIC TURNER TWINS: AN INTERESTING PRESENTATION.

Acta endocrinologica (Bucharest, Romania : 2005)·2025
Same author

High frequency of transient congenital hypothyroidism among infants referred for suspected congenital hypothyroidism from the Turkish National screening program: thyroxine dose may guide the prediction of transients.

Journal of endocrinological investigation·2024
Same author

Comparison of Bipolar vascular sealing and conventional back-table dissection in terms of post-renal transplant drainage and back-table preparation times.

European review for medical and pharmacological sciences·2023
Same author

TWO OPPOSITE PHENOTYPES OF GLUCOSE DISORDERS IN A FAMILY WITH HETEROZYGOUS P.SER453LEU (C.1358C> T) MUTATION IN THE GLUCOKINASE (GCK) GENE: MATURITY ONSET DIABETES IN YOUNG AND INSULINOMA.

Acta endocrinologica (Bucharest, Romania : 2005)·2023
Same journal

The many faces of cytokine storm syndrome: immunopathogenic mechanisms and clinical implications for a better patient management.

Clinical and experimental immunology·2026
Same journal

PD-1 Engagement and Circulating Th17 Effector Activity During Secukinumab Treatment in Plaque Psoriasis.

Clinical and experimental immunology·2026
Same journal

Henoch-Schoenlein purpura (HSP) like lesions in IL12RB1 and IL12B defects - A multi-centric experience from India.

Clinical and experimental immunology·2026
Same journal

Case Series on the Efficacy of Daratumumab in Treating Patients with Anti-Interferon-Gamma Autoantibodies.

Clinical and experimental immunology·2026
Same journal

Deleterious germline CARD11 gain-of-function variants alter human B-cell and CD4+ T-cell differentiation and function.

Clinical and experimental immunology·2026
Same journal

Clinical, genetic, and functional characterization of novel NFKB1 variants in Chinese patients with primary immunodeficiency.

Clinical and experimental immunology·2026
See all related articles

Monocyte-derived dendritic cells (MdDC) in common variable immunodeficiency (CVID) patients show maturation defects, impacting T cell responses and potentially explaining antibody production failure. This research highlights a subset of CVID patients with abnormal MdDC function.

Area of Science:

  • Immunology
  • Cell Biology
  • Genetics

Background:

  • Common variable immunodeficiency (CVID) is characterized by impaired antibody production.
  • Dendritic cells (DCs) play a crucial role in adaptive immunity and antigen presentation.
  • Understanding DC function in CVID is essential for elucidating disease mechanisms.

Purpose of the Study:

  • To investigate the phenotype and function of monocyte-derived dendritic cells (MdDCs) in CVID patients.
  • To identify potential abnormalities in MdDCs that contribute to the failure of antibody production in CVID.

Main Methods:

  • Phenotypic analysis of MdDCs using MHC class II DR and CD86 markers.
  • Assessment of MdDC capacity to support antigen-stimulated T cell proliferation.
  • Measurement of cytokine production (IL-8, IL-1a, IL-6, IL-12, IL-13, IL-10, IFN-gamma) by MdDCs.

Related Experiment Videos

Main Results:

  • Most CVID patients exhibited normal MdDC maturation markers (MHC class II DR, CD86).
  • A subset of 5 CVID patients showed low DR expression and reduced T cell proliferation support.
  • Many CVID patients displayed high spontaneous IL-8 production, with LPS often reducing DR expression.

Conclusions:

  • A subset of CVID patients possesses a fundamental defect in MdDC maturation.
  • This MdDC maturation defect may impair antigen presentation, contributing to poor antibody production in CVID.
  • Further research into genetic factors within the MHC region may be warranted for affected CVID subsets.