Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Optimization and statistical evaluation of dissolution tests for indinavir sulfate capsules.

B Carvalho-Silva1, L M Moreira-Campos, E A Nunan

  • 1Laboratório de Controle de Qualidade de Produtos Farmacêuticos e Cosméticos, Faculdade de Farmácia, Universidade Federal de Minas Gerais, Pampulha 31270-901, Belo Horizonte, MG, Brasil.

Farmaco (Societa Chimica Italiana : 1989)
|November 17, 2004
PubMed
Summary

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Toxic concentrations of metronidazole to Microcystis protocystis.

Brazilian journal of biology = Revista brasleira de biologia·2015
Same author

A novel non-antibacterial, non-chelating hydroxypyrazoline derivative of minocycline inhibits nociception and oedema in mice.

British journal of pharmacology·2008
Same author

Identification of lamivudine conformers by Raman scattering measurements and quantum chemical calculations.

Journal of pharmaceutical and biomedical analysis·2007
Same author

The influence of formulation on the dissolution profile of diclofenac sodium tablets.

Drug development and industrial pharmacy·2006
Same author

Age effects on the pharmacokinetics of tityustoxin from Tityus serrulatus scorpion venom in rats.

Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas·2004
Same author

Technetium-99m labeling of tityustoxin and venom from the scorpion Tityus serrulatus.

Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine·2002

This study optimized dissolution testing for indinavir sulfate capsules using statistical analysis. Optimal conditions were identified for accurate drug release assessment, ensuring product quality and efficacy.

Area of Science:

  • Pharmaceutical Sciences
  • Drug Development
  • Analytical Chemistry

Background:

  • Dissolution testing is critical for ensuring the quality and bioavailability of pharmaceutical products.
  • Establishing optimal dissolution test conditions is essential for accurate and reproducible drug release assessments.
  • Indinavir sulfate capsules require validated dissolution methods for quality control.

Purpose of the Study:

  • To optimize dissolution test conditions for indinavir sulfate capsules using a statistically based approach.
  • To identify the most suitable dissolution medium and apparatus for evaluating indinavir sulfate capsule dissolution profiles.
  • To ensure the reliability and statistical significance of dissolution test results.

Main Methods:

  • Statistical optimization using t-student tests to determine dissolution parameters.

Related Experiment Videos

  • Evaluation of three dissolution media and two apparatus (paddle and basket) with indinavir sulfate capsules (Products A and B).
  • Assay of 18 capsules per condition for statistical analysis and 12 dosage units for dissolution profile evaluation.

    • Main Results:

    • All tested media were statistically equivalent (P > 0.05) with the paddle apparatus at 50 rpm for both products.
    • The basket apparatus at 50 rpm significantly decreased drug release for Product B (P < 0.05).
    • Optimal conditions identified: 900 ml 0.1 M HCl, basket apparatus at 100 rpm, and 260 nm UV detection.

    Conclusions:

    • Statistically validated optimal conditions for indinavir sulfate capsule dissolution testing were established.
    • The identified conditions ensure accurate and reproducible assessment of drug release profiles.
    • These optimized methods contribute to robust quality control of indinavir sulfate formulations.