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Updated: Aug 9, 2026
Primary Culture of Mouse Dopaminergic Neurons
Published on: September 8, 2014
Immediate early gene expression in rat basal ganglia after destruction of the dopaminergic system
1Department of Neuropharmacology, University of Tübingen, Mohlstrasse 54/1, D-72074 Tübingen, Germany. vera.pedersen@uni-tuebingen.de
Abstract:
In the present study, we performed immunocytochemical mapping of cFos and c-Jun as markers for changes in neural activity in the brains of dopamine denervated rats. We observed a prolonged c-Fos and c-Jun expression in basal ganglia motor and limbic circuits over 96 h. This might be due to alterations in transmitter balances. We conclude, that changes in neural activities are involved in the development of 'extranigral' pathology of Parkinson's disease.
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