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Updated: Aug 20, 2026

Murine Drinking Models in the Development of Pharmacotherapies for Alcoholism: Drinking in the Dark and Two-bottle Choice
Published on: January 7, 2019
Functional genomics strategies to identify susceptibility genes and treatment targets in alcohol dependence
Markus Heilig1, Wolfgang Sommer
1Division of Psychiatry, NEUROTEC Department, Karolinska Institutet, M57 Huddinge University Hospital, S-141 86 Stockholm, Sweden. markus.heilig@neurotec.ki.se
Abstract:
Genetic factors contribute to alcohol dependence through two main categories of mechanisms. The 50-60% heritability observed in this disorder is presumably conferred by polymorphic variants, encoding functionally altered proteins, or leading to differential transcriptional activity. Secondly, long term changes during the process of developing dependence are likely encoded by persistent changes in gene expression. Thus, genetic and environmental factors interact at the level of the transcriptome, making this an attractive level of analysis. For this purpose, we have applied differential display and more recently Affymetrix oligonucleotide gene arrays to models of genetic susceptibility and alcohol-induced neuroadaptation.
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