Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

FADD and its phosphorylation.

Jing Zhang1, Dapeng Zhang, Zichun Hua

  • 1The State Key Laboratory of Pharmaceutical Biotechnology, and Institute of Molecular and Cell Biology, Nanjing Universtiy, Nanjing 210093, China.

IUBMB Life
|November 17, 2004
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Intelligent Veterinary Disease Management Driven by Knowledge Graph for Conservation Breeding of Captive Forest Musk Deer.

Veterinary sciences·2026
Same author

Optimizing the genomic bit budget: an information-theoretic framework for trait-enriched genotyping and stratified screening in <i>Theobroma cacao</i>.

Horticulture research·2026
Same author

Pharmacokinetics, safety, and efficacy of fuzuloparib in combination with abiraterone acetate and prednisone in patients with metastatic castration-resistant prostate cancer: a phase 1 dose escalation and expansion study.

BMC cancer·2026
Same author

Constraining near-term projections of the South Asian high and Afro-Asian summer monsoon rainfall.

Nature communications·2026
Same author

Keypoint-Based Forest Musk Deer Behavioral Recognition Method.

Animals : an open access journal from MDPI·2026
Same author

Affinity Capillary Electrophoresis for the Study of Biomolecular Interactions: Recent Advances and Future Perspectives.

Journal of separation science·2026

The adaptor protein FADD regulates apoptosis and cell proliferation. Its phosphorylation controls cellular activation, suggesting FADD acts as a key regulator of cell renewal.

Area of Science:

  • Cell Biology
  • Immunology
  • Molecular Biology

Background:

  • The adaptor protein FADD (Fas-associated death domain) is critical for apoptosis initiated by death receptors.
  • FADD mediates caspase-8 activation, crucial for programmed cell death.
  • FADD also plays a role in T and B cell development.

Purpose of the Study:

  • To investigate the additional roles of FADD beyond apoptosis.
  • To explore the involvement of FADD phosphorylation in cellular activation and proliferation.
  • To understand FADD's function as a potential regulator of cell renewal.

Main Methods:

  • Analysis of FADD's role in apoptosis pathways.
  • Investigating FADD's involvement in T and B cell development.
  • Exploring the impact of FADD phosphorylation on cellular processes.

Related Experiment Videos

Main Results:

  • FADD is implicated in regulating T and B cell development.
  • Evidence suggests FADD and its phosphorylation control cellular activation and proliferation pathways.
  • The specific kinase responsible for FADD phosphorylation remains unidentified.

Conclusions:

  • FADD is a pivotal molecule connecting apoptosis and proliferation.
  • FADD, potentially through phosphorylation, may act as a 'cell renewal set point'.
  • Further research is needed to identify the kinase and fully elucidate FADD's regulatory mechanisms.