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Updated: Aug 20, 2026

Examining the Characteristics of Episodic Memory using Event-related Potentials in Patients with Alzheimer's Disease
Published on: August 30, 2011
Neural basis for the cognitive continuum in episodic memory from health to Alzheimer disease
1Memory Clinic, Department of Neurology, University of Ulm, Steinhoevelstr. 1, 89075 Ulm, Germany.
Objective:
The authors hypothesize that, behaviorally, episodic memory in health and disease reflects a continuum.
Methods:
Subjects (N=12) with very mild Alzheimer disease (AD) and normal subjects (N=24) were investigated with functional magnetic resonance imaging (fMRI) during an episodic memory task.
Results:
Recruitment of a posterior medio-temporal network was correlated with memory performance across the spectrum from high- and low-performing normal subjects to patients with early AD.
Conclusions:
The behavioral spectrum from health to disease in episodic memory function is mirrored neurobiologically with graded recruitment of neuronal activation in medio-temporal regions. The results call for longitudinal assessment of behavioral decline and neuronal recruitment in future studies.
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