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Sex differences in brain structure in geriatric depression.

Helen Lavretsky1, Kristina Kurbanyan, Martina Ballmaier

  • 1Department of Psychiatry and Biobehavioral Sciences Laboratory of Neuro Imaging, David Geffen School of Medicine, University of California-Los Angeles, Los Angeles, CA 90095, USA. hlavrets@ucla.edu

The American Journal of Geriatric Psychiatry : Official Journal of the American Association for Geriatric Psychiatry
|November 17, 2004
PubMed
Summary
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This study found that men with late-life depression have smaller frontal brain volumes than women. Medical burden may influence these sex differences in brain anatomy, impacting geriatric depression.

Area of Science:

  • Neuroscience
  • Gerontology
  • Psychiatry

Background:

  • Late-life major depression (MDD) affects geriatric populations.
  • Sex differences in brain structure may play a role in MDD.
  • Frontal and orbito-frontal (OFC) regions are implicated in depression.

Purpose of the Study:

  • To investigate sex differences in frontal and OFC regional brain volumes in patients with late-life MDD.
  • To compare brain volumes between patients with MDD and age-matched controls.
  • To explore the influence of medical burden on these differences.

Main Methods:

  • 41 patients with MDD and 41 controls underwent neuropsychiatric evaluations and MRI scans.
  • Corrected frontal and OFC gray-matter volumes were analyzed.

Related Experiment Videos

  • Comparisons were made between sexes within and between groups, controlling for medical burden.

    • Main Results:

    • Patients with MDD showed smaller OFC volumes compared to controls.
    • Men, in both groups, exhibited smaller frontal-matter volumes than women.
    • A diagnosis by sex interaction in brain regional volumes emerged after accounting for medical burden.

    Conclusions:

    • Sex differences in neuroanatomy are potentially significant in geriatric depression.
    • Men may be more prone to frontal subregion atrophy.
    • Medical burden may mediate the observed diagnosis by sex interaction in brain volumes.