Measurements of ocular aberrations and light scatter in healthy subjects

To report and validate an optical imaging system that provides measurements of higher order ocular aberrations and light scatter in human eyes.

An optical imaging system has been established that provides for combined measurements of ocular aberrations and light scatter. A laser beam was expanded and focused to a point on the retina by the optics of the eye. Wavefront sensing was performed with a Shack-Hartmann aberrometer to determine the wavefront aberration function and calculate the point spread function, giving information on ocular aberrations. A cylindrical lens was placed in the path of the incident laser beam path, and the line spread function was derived from the laser slit, giving information on combined ocular aberrations and light scatter. A relative index for ocular light scatter was determined by subtracting the area under the two line spread functions. Measurements were performed in one eye of 20 normal healthy subjects. The subjects' ages ranged between 21 and 78 years, and the average for all the eyes was 43 +/- 17 years (mean +/- SD).

Higher order ocular aberrations were correlated with subjects' ages (r = 0.6; p = 0.01; N = 20). Combined higher order ocular aberrations and light scatter were correlated with age (r = 0.7; p = 0.0002; N = 20). Light scatter was correlated with age (r = 0.6; p = 0.002; N = 20).

A method was established to measure age-related changes in ocular higher order aberrations and light scatter. Differentiating the contribution of ocular aberrations and light scatter to the retinal image quality has potential value for anticipating the outcome of procedures that attempt to compensate for ocular aberrations and for providing information on factors that degrade the optical performance of the eye in health and disease.