Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Capillary Exchange01:28

Capillary Exchange

12.2K
The cardiovascular system's chief role is to disseminate gases, nutrients, waste, and other substances to the body's cells. Small molecules like gases, lipids, and lipid-soluble substances directly diffuse through capillary wall endothelial cell membranes. Glucose, amino acids, and ions, including sodium, potassium, calcium, and chloride, use transporters for facilitated diffusion via membrane-specific channels. Glucose, ions, and bigger molecules may also pass through intercellular...
12.2K
Renal Corpuscle01:20

Renal Corpuscle

8.4K
The glomerulus and Bowman's capsule are two essential components of the nephron, which is the functional unit of the kidney. These microscopic structures play a critical role in the process of blood filtration to produce urine.
Glomerulus: Structure and Function
The glomerulus is a tiny, intricate network of capillaries located at the beginning of the nephron. It's enveloped by the Bowman's capsule and receives its blood supply from an afferent arteriole, which divides into numerous...
8.4K
Glomerular Filtration01:15

Glomerular Filtration

7.5K
The filtration membrane in the renal system is a highly specialized structure essential for filtering blood. It consists of glomerular capillaries and podocytes, forming a selective barrier that permits the passage of water and small solutes while restricting most plasma proteins and blood cells.
Components of the Filtration Membrane
The filtration process involves three key layers: the glomerular endothelial cells, the basement membrane, and the podocyte-formed filtration slits.
7.5K
Glomerular Filtration Rate and its Regulation01:28

Glomerular Filtration Rate and its Regulation

5.9K
The Glomerular Filtration Rate (GFR) is a measure of kidney function, reflecting the volume of filtrate formed per minute in the kidneys. On average, GFR is approximately 125 mL/min in males and 105 mL/min in females. Maintaining a relatively constant GFR is essential for the kidneys to effectively regulate body fluid homeostasis and maintain extracellular stability.
GFR regulation involves two primary intrinsic controls: the myogenic and tubuloglomerular feedback mechanisms.
The myogenic...
5.9K
Renal Drug Excretion: Glomerular Filtration01:02

Renal Drug Excretion: Glomerular Filtration

2.1K
The kidney serves as the primary organ responsible for eliminating drugs and their metabolites from the body. This process, known as renal elimination, starts with glomerular filtration and results in urine formation. Each kidney houses millions of functional units called nephrons, where urine production occurs. A nephron has two main components: a renal corpuscle and a renal tubule.
Drugs gain access to the kidney via the renal artery, which progressively branches off into afferent arterioles....
2.1K
Glomerular Filtration: Net Filtration Pressure01:26

Glomerular Filtration: Net Filtration Pressure

10.1K
Glomerular filtration, a key process in the kidneys, is regulated by three main pressures: Glomerular blood hydrostatic pressure (GBHP), Capsular hydrostatic pressure (CHP), and Blood colloid osmotic pressure (BCOP).
GBHP, with an average value of 55 mmHg, promotes filtration by pushing water and solutes through the filtration membrane. This is balanced by two opposing forces: CHP, a "back pressure" exerted against the filtration membrane by fluid already in the capsular space and renal...
10.1K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A mathematical analysis of Prx2-STAT3 disulfide exchange rate constants for a bimolecular reaction mechanism.

Free radical biology & medicine·2018
Same author

A reaction-diffusion model of cytosolic hydrogen peroxide.

Free radical biology & medicine·2015
Same author

Analysis of the lifetime and spatial localization of hydrogen peroxide generated in the cytosol using a reduced kinetic model.

Free radical biology & medicine·2015
Same author

Discontinuous nanoporous membranes reduce non-specific fouling for immunoaffinity cell capture.

Small (Weinheim an der Bergstrasse, Germany)·2013
Same author

A nitrogen dioxide delivery system for biological media.

Free radical biology & medicine·2012
Same author

Nitric oxide produced endogenously is responsible for hypoxia-induced HIF-1α stabilization in colon carcinoma cells.

Chemical research in toxicology·2012
Same journal

ATR senses stiff extracellular matrix to promote epithelial-to-mesenchymal transition and immune suppression.

The Journal of clinical investigation·2026
Same journal

A peripheral subpopulation of retinal pigment epithelium resists oxidative damage through SERPINE3-mediated Caspase-1 inhibition.

The Journal of clinical investigation·2026
Same journal

PTEN deficiency confers sensitivity to ATR inhibitor-based treatment in high-grade serous ovarian cancer.

The Journal of clinical investigation·2026
Same journal

CD20+ T follicular helper-like cells drive antigen-specific autoimmunity in bullous pemphigoid.

The Journal of clinical investigation·2026
Same journal

Fate-mapping infiltrating monocytes following experimental myocardial infarction revealsdifferentiation trajectories in the infarcted heart.

The Journal of clinical investigation·2026
Same journal

Pharmacokinetics and pharmacodynamics of a long-acting monoclonal antibody against malaria in African adults.

The Journal of clinical investigation·2026
See all related articles

Related Experiment Video

Updated: May 4, 2026

Quantifying Glomerular Permeability of Fluorescent Macromolecules Using 2-Photon Microscopy in Munich Wistar Rats
11:13

Quantifying Glomerular Permeability of Fluorescent Macromolecules Using 2-Photon Microscopy in Munich Wistar Rats

Published on: April 17, 2013

10.0K

What determines glomerular capillary permeability?

William M Deen1

  • 1Department of Chemical Engineering, Division of Biological Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA. wmdeen@mit.edu

The Journal of Clinical Investigation
|November 17, 2004
PubMed
Summary
This summary is machine-generated.

Recent advances in glomerular slit diaphragm biology clarify how its structure and molecular components, along with the basement membrane and endothelium, collectively regulate kidney filtration. This improves our understanding of kidney barrier function.

More Related Videos

Assessment of Kidney Function in Mouse Models of Glomerular Disease
09:16

Assessment of Kidney Function in Mouse Models of Glomerular Disease

Published on: June 30, 2018

21.0K
Highly Sensitive Measurement of Glomerular Permeability in Mice with Fluorescein Isothiocyanate-polysucrose 70
09:16

Highly Sensitive Measurement of Glomerular Permeability in Mice with Fluorescein Isothiocyanate-polysucrose 70

Published on: August 9, 2019

6.2K

Related Experiment Videos

Last Updated: May 4, 2026

Quantifying Glomerular Permeability of Fluorescent Macromolecules Using 2-Photon Microscopy in Munich Wistar Rats
11:13

Quantifying Glomerular Permeability of Fluorescent Macromolecules Using 2-Photon Microscopy in Munich Wistar Rats

Published on: April 17, 2013

10.0K
Assessment of Kidney Function in Mouse Models of Glomerular Disease
09:16

Assessment of Kidney Function in Mouse Models of Glomerular Disease

Published on: June 30, 2018

21.0K
Highly Sensitive Measurement of Glomerular Permeability in Mice with Fluorescein Isothiocyanate-polysucrose 70
09:16

Highly Sensitive Measurement of Glomerular Permeability in Mice with Fluorescein Isothiocyanate-polysucrose 70

Published on: August 9, 2019

6.2K

Area of Science:

  • Nephrology
  • Molecular Biology
  • Structural Biology

Background:

  • The glomerular capillary wall, comprising endothelium, basement membrane, and slit diaphragm, acts as the primary filtration barrier in the kidney.
  • Understanding the molecular and structural biology of these components is crucial for comprehending kidney function and disease.

Discussion:

  • Recent studies have elucidated the structural and molecular intricacies of the glomerular slit diaphragm.
  • New data highlight the permeability characteristics of the glomerular basement membrane.
  • Emerging evidence suggests the glomerular endothelium plays a more significant role in filtration than previously recognized.

Key Insights:

  • The glomerular slit diaphragm's structural and molecular biology is advancing our knowledge of kidney filtration.
  • Integrating data on all three layers of the glomerular capillary wall provides a holistic view of kidney barrier function.
  • These combined insights are refining our understanding of how the kidney selectively filters blood.

Outlook:

  • Further research into the slit diaphragm's molecular interactions will deepen our understanding of nephrotic syndromes.
  • Investigating the interplay between the endothelium, basement membrane, and slit diaphragm may reveal novel therapeutic targets for kidney diseases.
  • Continued exploration of glomerular capillary wall biology promises to enhance diagnostic and therapeutic strategies in nephrology.