Endovascular interventions in iliac and infrainguinal occlusive artery disease
Johannes Ruef1, Manfred Hofmann, Jürgen Haase
1Red Cross Hospital Cardiology Center, Frankfurt, Germany. j.ruef@kardiocentrum-ffm.de
Insights
Endovascular procedures effectively treat peripheral artery disease, but long-term success varies by artery location. New strategies are needed to improve patency rates and update current guidelines.
Area of Science:
- Vascular Surgery
- Interventional Cardiology
- Endovascular Medicine
Background:
- Percutaneous endovascular procedures are common for symptomatic peripheral occlusive artery disease.
- High technical success rates are observed, but long-term patency differs based on anatomical location (iliac, femoropopliteal, infrapopliteal).
Purpose of the Study:
- To review the effectiveness of endovascular treatments for peripheral occlusive artery disease.
- To discuss current limitations and emerging strategies for improving long-term outcomes, particularly in challenging infrainguinal interventions.
Main Methods:
- Review of current literature on percutaneous endovascular procedures for peripheral occlusive artery disease.
- Analysis of factors influencing long-term patency rates in different arterial segments.
- Discussion of novel and investigational treatment modalities.
Main Results:
- Iliac artery interventions, especially with nitinol stents, show good long-term patency.
- Infrainguinal interventions face challenges with high restenosis rates, with optimal treatment methods still debated.
- Emerging techniques like drug-eluting stents and covered stent grafts show promise.
Conclusions:
- While endovascular techniques are successful, long-term patency varies significantly by anatomical region.
- High restenosis rates in femoropopliteal and infrapopliteal arteries necessitate further research and development of new strategies.
- Current consensus guidelines require reevaluation based on accumulated data and advancements in peripheral interventions.
Abstract:
Percutaneous endovascular procedures are increasingly applied to treat symptomatic peripheral occlusive artery disease. While the primary technical success and recanalization rates in iliac and infrainguinal interventions are high, differences in the long-term patency rates exist with respect to the anatomic localization, separating the iliac, femoropopliteal, and infrapopliteal arterial regions. In iliac arteries, even complex lesions can be recanalized with good long-term patency rates, especially when using self-expanding nitinol stents. In the infrainguinal arteries the method of choice is still under debate (e.g., balloon angioplasty vs stent implantation). A high restenosis rate represents one of the major limitations in femoropopliteal and infrapopliteal interventions. Therefore, additional methods and treatment strategies for peripheral interventions with the potential for future applications are under investigation and will be discussed such as drug-eluting stents, brachytherapy, subintimal angioplasty, laser angioplasty, atherectomy/thrombectomy, cutting balloon, polytetrafluoroethylene (PTFE)-covered stent grafts, biodegradable stents, and cryoplasty. The increasing amount of data on successful peripheral interventions supports the necessity to adapt and reevaluate the current consensus guidelines that were put together in 2000.
Related Concept Videos
Peripheral Artery Disease III: Interprofessional Care
Aneurysm III: Interprofessional Care
Venous Thrombosis III: Interprofessional Care
Arteries of Lower Limbs
Peripheral Artery Disease V: Postoperative Nursing Management
Abdominal Aorta
The celiac trunk, a singular artery, divides into the left gastric artery, which...
