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Prevalence of malignancy within cytologically indeterminate thyroid nodules
Barbara Miller1, Shelby Burkey, Guy Lindberg
1Department of Surgery, University of Texas Southwestern Medical Center, Department of Surgery, UT Southwestern Medical Center, 5323 Harry Hines Blvd., Dallas, TX, 75390-9156, USA.
American Journal of Surgery
|November 18, 2004
Summary
Cytologically indeterminate thyroid nodules have a high malignancy rate. Thyroidectomy may be necessary for patients with indeterminate follicular lesions identified by fine-needle aspiration biopsy (FNAB).
Area of Science:
- Endocrinology
- Cytopathology
- Surgical Oncology
Background:
- Management of cytologically indeterminate thyroid nodules is debated due to variable malignancy rates.
- This study investigates malignancy prevalence in indeterminate follicular thyroid lesions.
Purpose of the Study:
- To determine the prevalence of malignancy in cytologically indeterminate follicular thyroid lesions.
- To assess if cytologic features can predict malignancy in these lesions.
Main Methods:
- Retrospective analysis of cytopathology reports from fine-needle aspiration biopsy (FNAB) over 4 years.
- Determined malignancy prevalence in 4 indeterminate cytologic categories based on final histology.
Main Results:
- 107 records analyzed (91 women, 16 men; mean age 45.4 years).
- 48 patients (45%) had histopathologic diagnosis post-surgery.
- Malignancy prevalence was 42% (20/48) in patients who underwent thyroidectomy.
Conclusions:
- Indeterminate follicular lesions on FNAB show a high malignancy prevalence.
- Thyroidectomy may be indicated for patients with indeterminate follicular lesions on FNAB.