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Pregnancy in sickle cell disease in Bahrain
A M el-Shafei1, J K Dhaliwal, A K Sandhu
1Department of Obstetrics & Gynaecology, Salmaniya Medical Centre, Arabian Gulf University, State of Bahrain.
Objective:
To review the maternal and fetal complications in pregnant women with sickle cell disease and to compare their pregnancy outcome with those of controls.
Design:
A case-control study.
Setting:
Ministry of Health hospitals in Bahrain.
Subjects:
147 pregnancies in 140 women with sickle cell disease and 294 controls matched for age and parity.
Main Outcome Measures:
The characteristics of women who had crises, the frequency of the crises, hypertensive disorders of pregnancy, infection, diabetes, perinatal mortality and the delivery statistics in the index and control women.
Results:
Maternal mortality was 1.4% and perinatal mortality was 73.3/1000 total births in women with sickle cell disease, there were no maternal deaths and the perinatal mortality was 6.8/1000 births in the control group. Anaemia was treated by blood transfusion in 47% of women with sickle cell disease and, of these, 39% had a crisis that appeared to have been precipitated by the transfusion in the absence of any other predisposing factors. The presence of raised HbF did not decrease the number of crises but reduced their severity.
Conclusion:
Pregnancy in women with sickle cell disease should be monitored very closely as it constitutes a high risk to both the mother and the baby.