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Updated: Aug 20, 2026

Functionalized Spirocyclic Heterocycle Synthesis and Cytotoxicity Assay
Published on: February 9, 2021
Novel diarylsulfonylurea derivatives as potent antimitotic agents
Semi Kim1, Ji Hyun Park, Sun-Young Koo
1LG Life Sciences, Ltd/R&D Park, 104-1 Moonji-dong, Yuseong-gu, Daejon 305-380, South Korea. semikim@lgls.co.kr
Abstract:
A novel series of diarylsulfonylurea derivatives were synthesized and evaluated for interaction with tubulin and for cytotoxicity against human cancer cell lines. These derivatives demonstrated good inhibitory activity against tubulin polymerization, which was well correlated with promising antiproliferative activity as well as G2/M phase cell cycle arrest. Furthermore, several compounds were also efficacious against multidrug-resistant cancer cells, which are resistant to many other known microtubule inhibitors.
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