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Dysfunctional B cells in systemic lupus erythematosus
Yves Renaudineau1, Jacques-Olivier Pers, Boutahar Bendaoud
1Laboratory of Immunology, Brest University Medical School BP824, F29609 Brest cedex, France.
Autoimmunity Reviews
|November 18, 2004
Summary
B cells, beyond antibody production, have diverse immune functions that can contribute to autoimmune diseases. Understanding these roles is crucial for developing new treatments for conditions like lupus.
Area of Science:
- Immunology
- Autoimmunity
- B cell biology
Background:
- The traditional view of B cells solely producing antibodies (Ab) for immunity is incomplete.
- Emerging evidence reveals diverse B cell functions beyond Ab production, potentially contributing to autoimmunity.
- B cells play roles in lymphoid architecture, regulating dendritic cells (DC) and T cell subsets, and T cell activation.
Purpose of the Study:
- To explore the multifaceted roles of B cells in immune responses and autoimmunity.
- To highlight the significance of B cell functions beyond antibody production in autoimmune diseases.
Main Methods:
- Review of recent studies on B cell functions in immunity and autoimmunity.
- Analysis of transgenic (Tg) animal models investigating B cell receptor (BCR) signaling.
- Examination of negative signaling pathways involving molecules like CD5 and CD22 in maintaining tolerance.
Main Results:
- B cells exhibit diverse functions including cytokine production, regulation of immune cells, and T cell activation.
- Abnormalities in B cell subsets and B cell depletion efficacy in autoimmune diseases underscore their importance.
- Tg models show a correlation between B cell sensitivity to BCR cross-linking and autoimmunity.
Conclusions:
- B cells are pivotal players in autoimmunity, with functions extending far beyond antibody secretion.
- Negative signaling pathways are critical for maintaining immune tolerance.
- Re-evaluation of B cells as key contributors to autoimmune disorders is warranted.