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Related Experiment Videos

Is autism an autoimmune disease?

Paul Ashwood1, Judy Van de Water

  • 1Department of Internal Medicine, Division of Rheumatology, and UC Davis M.I.N.D. Institute, University of California, Davis, CA 95616, USA.

Autoimmunity Reviews
|November 18, 2004
PubMed
Summary

The immune system

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Area of Science:

  • Neuroscience
  • Immunology

Background:

  • Autism spectrum disorder (ASD) involves social and communication impairments.
  • The etiology of ASD is complex, with immune dysfunction proposed as a factor.
  • Existing research on immune system involvement in ASD yields inconclusive results.

Purpose of the Study:

  • To review current findings on immune function in ASD.
  • To examine the spectrum of autoimmune phenomena in children with ASD.

Main Methods:

  • Literature review of studies on immune function and autoimmunity in ASD.
  • Analysis of reported immune system abnormalities in children with ASD.

Main Results:

  • Immune system abnormalities are reported in children with ASD.
  • There is a lack of consensus on the specific nature of these immune differences.
  • Reported differences include both enhanced autoimmunity and reduced immune function.

Conclusions:

  • The role of the immune system in ASD requires further investigation.
  • Understanding immune system involvement may offer new insights into ASD etiology and potential interventions.

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