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Updated: Aug 20, 2026
A Protein Microarray Assay for Serological Determination of Antigen-specific Antibody Responses Following Clostridium difficile Infection
Published on: June 15, 2018
IgM-enriched immunoglobulin (pentaglobin) positively influences the course of post-surgical intra-abdominal
H B Reith1, S K Rauchschwalbe, U Mittelkötter
1Department of Surgery, Klinikum Konstanz, Luisenstrasse 7, D-78464-Konstanz, Germany. bernd.reith@klinikum-konstanz.de
Background:
Polyvalent IgM-enriched intravenous human immunoglobulin (IVIG) preparations are discussed to be beneficial regarding sepsis outcome.
Materials And Methods:
Sixty-four patients with abdominal infection were treated with Pentaglobin or Albumin. Serum levels of endotoxin and chemokines were determined.
Results:
Incidence of fever was 19/28 in the pentaglobin and 18/26 in the albumin group, the percentage of days with fever was 34 +/- 26 for pentaglobin and 43 +/- 25 for albumin (mean +/-SD). Procalcitonin levels of the pentaglobin treated patients fell under the upper limit of normal on day six whereas levels of albumin patients remained elevated.
Conclusion:
Pentaglobin has a positive influence on the course of post-surgery intra-abdominal infection.
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