Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

CyDAS: a cytogenetic data analysis system.

Bernhard Hiller1, Jutta Bradtke, Harald Balz

  • 1Institut für Klinische Genetik der Phillipps-Universität Marburg, Bahnhofstrasse 7, 35037 Marburg, Germany.

Bioinformatics (Oxford, England)
|November 18, 2004
PubMed
Summary

A new program translates cancer cytogenetic karyotypes into numerical codes for statistical analysis. This tool extracts chromosomal gains, losses, and breakpoints, preparing genomic data for further research.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

XRCC4-related microcephalic primordial dwarfism: description of a clinical series of 7 cases, phenotype expansion and new diagnostic approaches.

European journal of human genetics : EJHG·2025
Same author

PAX5::AUTS2 childhood B-ALL: a relapse-prone genetic subtype with frequent central nervous system involvement and a poor outcome.

Leukemia·2024
Same author

Attributable deaths in Austria due to ozone under different climate scenarios.

European journal of public health·2024
Same author

Global impacts of an extreme solar particle event under different geomagnetic field strengths.

Proceedings of the National Academy of Sciences of the United States of America·2024
Same author

Characterization of IG-MYC-breakpoints and their application for quantitative minimal disease monitoring in high-risk pediatric Burkitt-lymphoma and -leukemia.

Leukemia·2022
Same author

Molecular characterization and clinical outcome of B-cell precursor acute lymphoblastic leukemia with IG-MYC rearrangement.

Haematologica·2022

Area of Science:

  • Cancer Cytogenetics
  • Bioinformatics
  • Genomic Data Analysis

Background:

  • Karyotype data in cancer cytogenetics requires numerical coding for statistical analysis.
  • Existing methods for translating genomic changes from karyotypes can be complex and time-consuming.

Purpose of the Study:

  • To develop a program for extracting and compiling chromosomal gains, losses, and breakpoints from karyotypes.
  • To facilitate the integration of karyotype data into statistical analyses for cancer research.

Main Methods:

  • Development of a software program to parse karyotype information.
  • Extraction of specific genomic alterations: chromosomal gains, losses, and breakpoints.
  • Compilation of extracted data into tabular formats and visualization on chromosome ideograms.

Related Experiment Videos

Main Results:

  • The program successfully extracts chromosomal gains, losses, and breakpoints from karyotypes.
  • Generated data is organized for direct use in statistical analysis pipelines.
  • The software is available as both a desktop and internet application.

Conclusions:

  • The developed program provides an efficient method for numerical encoding of karyotype data.
  • This facilitates advanced statistical analysis of genomic changes in cancer cytogenetics.
  • The tool enhances accessibility and usability of karyotype information for researchers.