Koningic acid (heptelidic acid) inhibition of glyceraldehyde-3-phosphate dehydrogenases from various sources
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Biochimica Et Biophysica Acta
|March 27, 1992
Abstract:
Koningic acid is a potent inhibitor of glyceraldehyde-3-phosphate dehydrogenase (GAPDH), which binds to the cysteine residue at the active site. We have determined sensitivity of GAPDHs in comparison with their amino acid sequences. It was found that koningic acid sensitivity of GAPDHs is highly dependent on the sequences of the S-loop domain of the enzyme.