Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Clinical trials with sigma ligands.

H-P Volz1, K D Stoll

  • 1Krankenhaus für Psychiatrie und Psychotherapie Schloss Werneck, Balthasar-Neumann-Platz 1, D-97440 Werneck, Germany. hans-peter-volz@kh-schloss-werneck.de

Pharmacopsychiatry
|November 18, 2004
PubMed
Summary

Sigma receptor ligands like igmesine and siramisine show potential for functional diarrhea, depression, and anxiety. Opipramol

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

[Pain and sleep disturbances].

MMW Fortschritte der Medizin·2016
Same author

[Therapeutic effects of venlafaxine extended release for patients with depressive and anxiety disorders in the German outpatient setting - results of 2 observational studies including 8500 patients].

Fortschritte der Neurologie-Psychiatrie·2009
Same author

[Cognitive disorders in schizophrenic patients].

Der Nervenarzt·2009
Same author

[Diagnosis and treatment of anxiety disorders].

MMW Fortschritte der Medizin·2008
Same author

Importance of open access to atypical antipsychotics for the treatment of schizophrenia and bipolar disorder: a European perspective.

Current medical research and opinion·2008
Same author

31P-MR spectroscopy in children and adolescents with a familial risk of schizophrenia.

European radiology·2003

Area of Science:

  • Neuroscience
  • Pharmacology
  • Psychiatry

Background:

  • Sigma ligands have been explored for various central nervous system disorders.
  • Previous investigations targeted functional diarrhea, depression, anxiety, schizophrenia, and somatoform disorders.

Purpose of the Study:

  • To review the therapeutic potential of sigma ligands.
  • To evaluate the clinical efficacy of specific sigma ligands, including igmesine, siramisine, and opipramol.

Main Methods:

  • Review of human and animal studies involving sigma ligands.
  • Analysis of pharmacological profiles and clinical outcomes.

Main Results:

  • Igmesine demonstrated efficacy in functional diarrhea and depression models, but development ceased.
  • Siramisine showed anxiolytic properties but was discontinued.
  • Opipramol exhibited broad efficacy in generalized anxiety and somatoform disorders, acting via sigma receptors.

Conclusions:

  • Opipramol's efficacy in anxiety and somatoform disorders may be mediated through sigma receptor activity.
  • Despite promising preclinical data, marketing and development issues have halted progress for some selective sigma ligands.

Related Experiment Videos