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Updated: Jul 17, 2026

Visualizing Single-molecule DNA Replication with Fluorescence Microscopy
Published on: October 9, 2009
Electron transfer rates in DNA films as a function of tether length
T Gregory Drummond1, Michael G Hill, Jacqueline K Barton
1Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, California 91125, USA.
Abstract:
A homologous series of DNA-modified electrodes has been investigated in which the molecular tether length varies. Using intercalated, covalently bound daunomycin as a redox probe, an exponential dependence of electron transfer rates on the number of intervening methylene groups in the sigma-bonded tether is observed. In contrast, variation in DM position within DNA yields no detectable change in rate. These data confirm that overall electron transfer rates in DNA films are limited by the tether, not the DNA.
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