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Facile synthesis of @-tide beta-strand peptidomimetics: improved assembly in solution and on solid phase
Scott T Phillips1, Giovanni Piersanti, Matthias Rüth
1Center for New Directions in Organic Synthesis, Department of Chemistry, University of California, Berkeley, CA 94720-1460, USA.
Organic Letters
|November 19, 2004
Abstract:
The synthesis of @-tide beta-strand peptidomimetics has been improved such that oligomers now can be obtained from solution- and solid-phase synthesis protocols approaching the efficiency and flexibility of peptide chemistry. These methods enable the synthesis of @-tide oligomers with a variety of amino acids and with lengths up to 13 units. [reaction: see text]