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Cellular distribution and functions of P2 receptor subtypes in different systems
Geoffrey Burnstock1, Gillian E Knight
1Autonomic Neuroscience Institute, Royal Free and University College Medical School, London NW3 2PF, United Kingdom.
International Review of Cytology
|November 19, 2004
Summary
This review details the distribution and function of P2 receptors throughout the body. It covers P2X and P2Y receptor subtypes, their expression changes, and future purinergic signaling research.
Area of Science:
- Pharmacology and Cell Biology
- Focuses on purinergic signaling and P2 receptors.
Background:
- Purinergic signaling involves extracellular nucleotides acting on P2 receptors.
- P2 receptors are crucial in various physiological and pathological processes.
Purpose of the Study:
- To provide a comprehensive reference on P2 receptor distribution and function across all body systems.
- To detail the historical context, molecular evidence, and functional roles of P2X and P2Y receptors.
Main Methods:
- Literature review synthesizing historical data up to 1994.
- Summary of evidence for P2X and P2Y receptor subtype mRNA and protein expression.
- Inclusion of functional data and discussion of receptor plasticity.
Main Results:
- Comprehensive overview of P2 receptor distribution and function in diverse organs and cells.
- Detailed account of P2X and P2Y receptor subtypes, including their molecular and functional characteristics.
- Analysis of P2 receptor expression plasticity during development, aging, and disease.
Conclusions:
- P2 receptors are widely distributed and functionally significant throughout the body.
- Understanding P2 receptor dynamics is key to comprehending physiological and pathophysiological states.
- Future research directions in purinergic signaling are highlighted.
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