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Umbilical cord blood transplantation
Vanderson Rocha1, Guillermo Sanz, Eliane Gluckman
1Eurocord Office, Bone Marrow Transplant, Hematology Department, Hôpital Saint Louis, Paris, France. vanderson.rocha@sls.ap-hop-paris.fr
Current Opinion in Hematology
|November 19, 2004
Summary
Unrelated donor cord blood transplantation is an acceptable alternative to bone marrow transplants for children and adults. Research is ongoing to optimize cord blood transplantation outcomes, focusing on cell dose and human leukocyte antigen matching.
Area of Science:
- Hematology
- Transplantation Immunology
Background:
- Umbilical cord blood (UCB) is a viable source of hematopoietic stem cells for transplantation.
- UCB transplantation offers advantages over bone marrow transplantation, including faster donor availability and tolerance of human leukocyte antigen (HLA) mismatches.
Purpose of the Study:
- To review recent clinical outcomes of UCB transplantation.
- To discuss research strategies for optimizing UCB transplantation.
Main Methods:
- Review of recent clinical results of cord blood transplantation.
- Discussion of developing research strategies.
Main Results:
- Unrelated donor UCB transplantation is an acceptable option for pediatric transplantation.
- Emerging data suggest UCB transplantation is also suitable for adults.
Conclusions:
- UCB transplantation is a valuable alternative to bone marrow transplantation.
- Further research is needed to optimize UCB transplantation by focusing on cell dose and HLA matching.