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Cancer Therapies

Cancer Therapies

Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...

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Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...

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The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...

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The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
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Related Experiment Video

Updated: Jul 6, 2026

Testing Targeted Therapies in Cancer using Structural DNA Alteration Analysis and Patient-Derived Xenografts

Testing Targeted Therapies in Cancer using Structural DNA Alteration Analysis and Patient-Derived Xenografts

Published on: July 25, 2020

Targeted cancer therapy.

Charles Sawyers¹

¹Howard Hughes Medical Institute, David Geffen School of Medicine at UCLA, Jonsson Comprehensive Cancer Center, 10833 LeConte Avenue, Los Angeles, California 90095, USA. csawyers@mednet.ucla.edu

|November 19, 2004

Summary

Cancer arises from disrupted cell-cycle regulation. Understanding molecular changes and the tumor microenvironment offers new therapeutic targets for effective cancer treatment.

Area of Science:

Oncology
Molecular Biology
Cell Biology

Background:

Cancer development is fundamentally linked to the dysregulation of cell-cycle progression and division.
Complex interactions involving regulatory factors, the tumor microenvironment, and cellular stress responses (e.g., DNA damage) govern cancer cell fate (proliferation vs. apoptosis).

Purpose of the Study:

To highlight recent advancements in understanding the molecular underpinnings of cancer.
To underscore the potential for developing targeted therapies based on this knowledge.

Main Methods:

Review of current molecular and cellular biology research on cancer regulation.
Analysis of the interplay between genetic factors, the tumor microenvironment, and stress signaling pathways.

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Main Results:

Identification of critical molecular disruptions in cell-cycle control as central to oncogenesis.
Elucidation of the role of complex regulatory networks and microenvironmental cues in cancer progression.

Conclusions:

Advances in molecular understanding provide a basis for rationally designed, targeted cancer therapies.
Targeting specific malfunctioning molecules and pathways holds promise for improving treatment efficacy.