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Tissue repair and stem cell renewal in carcinogenesis

Philip A Beachy1, Sunil S Karhadkar, David M Berman

  • 1Department of Molecular Biology and Genetics, The Howard Hughes Medical Institute, Baltimore, Maryland 21205, USA. pbeachy@jhmi.edu

Nature
|November 19, 2004
PubMed
Summary

Cancer is viewed as a stem cell disease, originating from normal tissue stem cells. Carcinogenesis may hijack normal tissue repair and stem cell renewal pathways, like Hedgehog and Wnt signaling, for uncontrolled growth.

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