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Novel angiotensin peptides
1The Hypertension and Vascular Disease Center, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA. cferrari@wfubmc.edu.
Cellular and Molecular Life Sciences : CMLS
|November 19, 2004
Summary
The discovery of angiotensin-(1-7) [Ang-(1-7)] reveals a new mechanism within the renin-angiotensin system. This peptide antagonizes angiotensin II (Ang II) effects, potentially altering our understanding of blood pressure and salt/water balance regulation.
Area of Science:
- Physiology
- Pharmacology
- Biochemistry
Background:
- The renin-angiotensin system (RAS) regulates blood pressure and tissue homeostasis.
- Angiotensin II (Ang II) is a key peptide in RAS, with known amplifiers and inhibitors like prostacyclin, bradykinin, and nitric oxide.
- Existing research focused on factors amplifying or inhibiting Ang II actions.
Purpose of the Study:
- To review the biological actions of angiotensin-(1-7) [Ang-(1-7)].
- To discuss how the discovery of Ang-(1-7) impacts the understanding of RAS function.
- To explore the role of Ang-(1-7) in regulating tissue perfusion pressure and salt/water metabolism.
Main Methods:
- Review of existing literature on RAS.
- Examination of advances in receptor pharmacology and selective Ang II receptor antagonists.
- Analysis of biochemical pathways within the RAS.
Main Results:
- Angiotensin II (Ang II) actions can be potentiated by various factors.
- A limited number of substances inhibit Ang II, including prostacyclin, bradykinin, and nitric oxide.
- The RAS can produce angiotensin-(1-7) [Ang-(1-7)], a peptide that antagonizes Ang II effects.
Conclusions:
- Angiotensin-(1-7) [Ang-(1-7)] acts as an antagonist to Ang II.
- The discovery of Ang-(1-7) suggests a more complex function of the renin-angiotensin system.
- This finding may reshape the perception of RAS in regulating blood pressure and fluid balance.