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Related Experiment Videos

Novel angiotensin peptides.

C M Ferrario1, M C Chappell

  • 1The Hypertension and Vascular Disease Center, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA. cferrari@wfubmc.edu.

Cellular and Molecular Life Sciences : CMLS
|November 19, 2004
PubMed
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The discovery of angiotensin-(1-7) [Ang-(1-7)] reveals a new mechanism within the renin-angiotensin system. This peptide antagonizes angiotensin II (Ang II) effects, potentially altering our understanding of blood pressure and salt/water balance regulation.

Area of Science:

  • Physiology
  • Pharmacology
  • Biochemistry

Background:

  • The renin-angiotensin system (RAS) regulates blood pressure and tissue homeostasis.
  • Angiotensin II (Ang II) is a key peptide in RAS, with known amplifiers and inhibitors like prostacyclin, bradykinin, and nitric oxide.
  • Existing research focused on factors amplifying or inhibiting Ang II actions.

Purpose of the Study:

  • To review the biological actions of angiotensin-(1-7) [Ang-(1-7)].
  • To discuss how the discovery of Ang-(1-7) impacts the understanding of RAS function.
  • To explore the role of Ang-(1-7) in regulating tissue perfusion pressure and salt/water metabolism.

Main Methods:

  • Review of existing literature on RAS.
  • Examination of advances in receptor pharmacology and selective Ang II receptor antagonists.

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  • Analysis of biochemical pathways within the RAS.

    • Main Results:

    • Angiotensin II (Ang II) actions can be potentiated by various factors.
    • A limited number of substances inhibit Ang II, including prostacyclin, bradykinin, and nitric oxide.
    • The RAS can produce angiotensin-(1-7) [Ang-(1-7)], a peptide that antagonizes Ang II effects.

    Conclusions:

    • Angiotensin-(1-7) [Ang-(1-7)] acts as an antagonist to Ang II.
    • The discovery of Ang-(1-7) suggests a more complex function of the renin-angiotensin system.
    • This finding may reshape the perception of RAS in regulating blood pressure and fluid balance.