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Updated: Aug 7, 2026

Ex Vivo Infection of Human Lymphoid Tissue and Female Genital Mucosa with Human Immunodeficiency Virus 1 and Histoculture
Published on: October 12, 2018
Pleurocerebral Nocardia in a patient with human immunodeficiency virus
1Department of Pharmaceutical Services, Mercy Hospital and Medical Center, Chicago, IL 60616.
Objective:
To report a case of Nocardia asteroides pneumonia and subsequent brain abscess in an immunocompromised host.
Setting:
Private, community, teaching hospital.
Patient:
A man readmitted to the hospital for a third time with a fatal brain abscess, after responding to (misdirected) therapy in previous admissions.
Interventions:
Treatment with cefuroxime, erythromycin, trimethoprim/sulfamethoxazole at different times.
Results:
Patient's condition deteriorated and he died after one month of intravenous trimethoprim/sulfamethoxazole therapy.
Conclusions:
Because it is an infection of the immunocompromised host, it may be considered an AIDS-defining illness. Several other similar cases have been reported in the literature.
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