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Aerosolized vancomycin therapy facilitating nursing home placement
J D Gradon1, E H Wu, L I Lutwick
1Division of Infectious Diseases, Maimonides Medical Center, Brooklyn.
Objective:
To demonstrate a novel method of eliminating nasopharyngeal colonization by methicillin-resistant Staphylococcus aureus (MRSA) in a debilitated, hospitalized patient.
Design:
Single-patient, nonblind, nonplacebo, case study.
Setting:
Community hospital, Brooklyn, NY.
Patient:
Hospitalized patient with recalcitrant nasopharyngeal MRSA colonization that could not be eliminated by conventional therapeutic interventions.
Interventions:
Aerosolized vancomycin hydrochloride 120 mg q6h administered in room air via face mask together with vancomycin nasal drops, 2 drops to each nostril q6h.
Main Outcome Measure:
Elimination of MRSA from the nasopharynx of the patient.
Results:
Successful elimination of MRSA colonization after four days of therapy.
Conclusions:
Aerosolized vancomycin in combination with vancomycin nasal drops is beneficial in eliminating nasopharyngeal colonization by MRSA. Clinical trials are warranted to confirm this clinical observation.