Trypanocidal activity of a new diterpene from Casearia sylvestris var. lingua
Laila Salmen Espindola1, José Rossy e Vasconcelos Júnior, Mariana Laundry de Mesquita
1Laboratório de Farmacognosia, Faculdade de Ciências da Saúde, Universidade de Brasília, Brasília, Brazil. darvenne@unb.br
Abstract:
Bioassay-guided fractionation of the hexanic root bark extract of Casearia sylvestris var. lingua led to the isolation of a new clerodane diterpene, whose structure was elucidated as rel-(2 S,5 R,6 R,8 S,9 S,10 R,18 S,19 R)-19-acetoxy-18,19-epoxy-6-hydroxy-18-butanoyloxy-2-(2-methylbutanoyloxy)cleroda-3,13(16), 14-triene by spectroscopic means, including 1D and 2D NMR analyses. This compound showed pronounced activity on Trypanosoma cruzi, the casual agent of Chagas' disease, with minimal inhibitory concentration (MIC) at 0.59 microg/mL.
