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Related Experiment Videos

CD11b Expression on circulating leukocytes increases in preparation for parturition.

Patrizia Luppi1, Tracy E Irwin, Hyagriv Simhan

  • 1Department of Pediatrics, Division of Immunogenetics, Children's Hospital of Pittsburgh, Pittsburgh, PA 15213, USA.

American Journal of Reproductive Immunology (New York, N.Y. : 1989)
|November 20, 2004
PubMed
Summary

Maternal leukocytes show increased CD11b expression near the end of pregnancy. This suggests CD11b is crucial for immune cell trafficking to the reproductive tract during parturition.

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Area of Science:

  • Immunology
  • Reproductive Biology
  • Cellular Biology

Background:

  • Parturition involves leukocyte migration to the reproductive tract, regulated by adhesion molecules.
  • Endothelial adhesion molecules like ICAM-1 increase in the reproductive tract during late gestation.
  • ICAM-1 interacts with the leukocyte beta(2) integrin CD11b.

Purpose of the Study:

  • To investigate complementary changes in maternal leukocyte adhesion molecule expression.
  • To understand leukocyte preparation for parturition.

Main Methods:

  • Flow cytometry was employed to analyze adhesion molecule expression.
  • Leukocyte samples were collected from women in the third trimester and during labor.

Main Results:

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  • A significant increase in CD11b expression was observed on monocytes and granulocytes.
  • This increase was noted in women beyond 37 weeks of gestation.

Conclusions:

  • CD11b upregulation on maternal leukocytes is a key event in preparation for parturition.
  • CD11b likely plays a critical role in leukocyte trafficking to the reproductive tract at the end of pregnancy.